Barrett's oesophagus with indefinite for dysplasia shows high rates of prevalent and incident neoplasia in a UK multicentre cohort

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dc.contributor.authorKopczynska, Maja
dc.contributor.authorRatcliffe, Elizabeth
dc.contributor.authorYalamanchili, Harika
dc.contributor.authorThompson, Anna
dc.contributor.authorNimri, Adib
dc.contributor.authorBritton, James
dc.contributor.authorAng, Yeng
dc.date.accessioned2023-09-19T10:58:36Z
dc.date.available2023-09-19T10:58:36Z
dc.date.issued30/09/2022
dc.description.abstractAims Barrett's oesophagus with indefinite for dysplasia (IDD) carries a risk of prevalent and incident dysplasia and oesophageal adenocarcinoma. This study seeks to determine the risk of neoplasia in a multicentre prospective IDD cohort, along with determining adherence to British Society of Gastroenterology (BSG) guidelines for management and histology reporting. Methods This was a cohort study using prospectively collected data from pathology databases from two centres in the North West of England (UK). Cases with IDD were identified over a 10-year period. Data were obtained on patient demographics, Barrett's endoscopy findings and histology, outcomes and histological reporting. Results 102 biopsies with IDD diagnosis in 88 patients were identified. Endoscopy was repeated in 78/88 (88%) patients. 12/78 progressed to low-grade dysplasia (15% or 2.6 per 100 person years), 6/78 (7.7%, 1.3 per 100 person years) progressed to high-grade dysplasia and 6/78 (7.7%, 1.3 per 100 person years) progressed to oesophageal adenocarcinoma. The overall incidence rate for progression to any type of dysplasia was 5.1 per 100 person years. Cox regression analysis identified longer Barrett's segment, multifocal and persistent IDD as predictors of progression to dysplasia. Histology reporting did not meet 100% adherence to the BSG histology reporting minimum dataset prior to or after the introduction of the guidelines. Conclusions IDD carries significant risk of progression to dysplasia or neoplasia. Therefore, careful diagnosis and management aided by clear histological reporting of these cases is required to diagnose prevalent and incident neoplasia.
dc.identifier.citationJ Clin Pathol. Published online September 23, 2022:jcp-2022-208524. doi:10.1136/jcp-2022-208524
dc.identifier.doi10.1136/jcp-2022-208524
dc.identifier.scopusRatcliffe, Elizabeth G. - Author details - Scopus Preview
dc.identifier.scopusYalamanchili, Harika - Author details - Scopus Preview
dc.identifier.urihttps://wwl.dspace-express.com/handle/20.500.13063/81
dc.language.isoen
dc.publisherBMJ Journals
dc.subjectGastrointestinal NeoplasmsEN
dc.subjectBarrett's OesophagusEN
dc.titleBarrett's oesophagus with indefinite for dysplasia shows high rates of prevalent and incident neoplasia in a UK multicentre cohort
dc.typeArticle
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